New antimicrobials added to WHO’s essential medicines list
New antimicrobials to treat serious bacterial and fungal infections were among the drugs that the World Health Organization (WHO) has included in its new essential drugs list, which is updated annually and serves as a recommended list of drugs. that every health care system should have.
For infectious diseases, the new inclusions include cefiderocol, listed as a “reserve” drug which should be accessible but is reserved for the treatment of confirmed or suspected multidrug-resistant infections. The reserve designation is part of the WHO Access, Watch, and Reserve (AWaRe) classification database, developed in 2017 to guide antimicrobial stewardship actions.
Other additions to infectious diseases include echinocandin-based antifungals, as well as monoclonal antibodies for the prevention of rabies. The list includes new drug formulations for common bacterial infections, including tuberculosis, to better meet dosage and administration needs in children and adults.
WHO has also classified 81 other antibiotics under the AWaRe.
October 1 WHO declaration
CDC: 140 more Salmonella cases of unknown origin, 419 in total
The Centers for Disease Control and Prevention (CDC) in an update yesterday confirmed 140 more cases in an outbreak of Salmonella Oranienburg diseases without a confirmed food source, bringing the epidemic total to 419 cases and 66 hospitalizations in 35 states.
So far, no deaths have been reported in this outbreak. The illnesses began on dates ranging from June 19 to September 14, the CDC said. The CDC first announced the outbreak on September 17, and cases have increased at a significant rate.
“The actual number of people sick during an outbreak is probably much higher than the number reported, and the outbreak may not be limited to states with known illnesses. This is because many people recover without care. medical and are not tested for Salmonella”, the CDC said.
Numerous investigations into the source of the epidemic are underway. Texas has the highest number of reported cases, with 111, followed by Oklahoma (63) and Virginia (38). Six states reported their first cases.
Sep 30 CDC update
Sep 24 Analysis of CIDRAP news on the previous update
Cases increase in plague epidemic in Madagascar
The number of cases in Madagascar’s outbreak has risen to 42, of which 22 are confirmed, the WHO announced today in an update based on data from September 15. So far, eight deaths have been reported among the confirmed cases, for one fatal case. rate of 37%.
Of the 22 confirmed cases, 19 patients had pulmonary plague, the most severe form of the disease, and 3 had the bubonic version.
So far, cases are being reported in two separate regions: Itasy in the central part of the country and Haute Matsiatra in the south-central part of the country. The plague is endemic in both regions, and both were severely affected during a large epidemic in 2017.
Health officials have identified 1,064 close contacts for follow-up and treatment. The first results of the animal survey reveal that 1.3% of the rats carry Yersinia pestis, the bacterium responsible for plague, a level above the alert threshold of 1%. However, the number of fleas collected from the captured rats did not exceed the alert threshold.
WHO said cases of plague are reported in Madagascar every year and usually occur from September to April. The main affected area is the central highlands, where the current epidemic is occurring.
The risks of spread to urban areas and other parts of the country are high, due to the proximity of the current outbreak to the country’s capital, Antananarivo.
October 1 WHO update
Two countries report more vaccine-related polio cases
Two African countries, Madagascar and Senegal, reported polio cases this week, both involving vaccine-derived subtypes, the Global Polio Eradication Initiative (GMIP) said in its latest update. weekly day.
Madagascar has reported two cases of circulating poliovirus derived from a type 1 vaccine strain (cVDPV1), one in Boeni and one in Menabe. The country has now reported eight such cases for 2021. For comparison, it has reported two cases of cVDPV1 in 2020.
Elsewhere, Senegal reported a circulating case of vaccine-derived poliovirus type 2 (cVDPV2), which was reported in Kaolack, bringing its total for the year to 14.
Sep 30 Weekly IMEP update